Consumer Labs recognizes this as safe ingredient for supplements, and it is found in many CoQ10 supplements on their website. The FDA recognizes Tween 80 as a GRAS product. The designation (GRAS) means Generally Recognized As Safe. The GRAS designation is an FDA government designation that a chemical or substance added to food is considered safe by experts, and is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. We remind folks that the FDA also provides the safety requirements and laws for the manufacture of all supplements and pharmaceuticals including supplement GMP processes and regulations that all biotech, food and vitamin manufacturers must follow regarding medicine, dietary supplements, Ice cream and everyday foods. Based on their safety record, Polysorbates are also approved for use in parenteral products. As a food additive, Tween 80 is used in many foods that you find in your favorite supermarket, some of them are listed here: Gelatin Desserts, Ice Creams, Cottage Cheese, Pickles, Vitamins/Mineral Preparations, Shortenings, Whipped Toppings, Barbecue Sauce, etc. If it were found toxic by the FDA experts, it simply would not be allowed in any of our common foods such as ice cream, cottage cheese, pickles or others commonly eaten by adults and children alike. If you have eaten a few of these things at a party or gathering, then you have already have had this safe product without knowing it. Nitro250 products are completely safe and provide a higher absorption than micronized resveratrol alone. Recommended Dosage: Because of the estimated increased absorption, we recommend only 1 capsule a day. Resveratrol has been found to be stable. The trans- form can undergo isomerisation to the cis- form when exposed to ultraviolet irradiation.[1] Trans-resveratrol in the powder form was found to be stable under "accelerated stability" conditions of 75% humidity and 40 degrees C in the presence of air.[2] Resveratrol content also stayed stable in the skins of grapes and pomace taken after fermentation and stored for a long period.[3] Having explained resveratrol's good stability, each individual capsule of the Nitro 250 product, is opaque and filled with nitrogen and protected for long term storage even if you take out the capsules from bottles and decide to transfer them to another container. If long term storage is important, and you want the product to last more than 2 years even after opening the bottle, this is the product to purchase. [1]. "Direct HPLC Analysis of cis- and trans-Resveratrol and Piceid Isomers in Spanish Red Vitis vinifera Wines". Lamuela-Raventos, RM (1995). [2]. "Resveratrol and its glycon piceid are stable polyphenols". Prokop J, Abrman P, Seligson AL, Sovak M (2006). [3]. "Stability of resveratrol over time and in the various stages of grape transformation". Bertelli AA, Gozzini A, Stradi R, Stella S, Bertelli A (1998). In studies, resveratrol is suggested to be a weak inhibitor of the P450 3A4 liver metabolism system, which is of unknown significance for humans. Taking large amounts of resveratrol may increase blood levels of drugs that are usually metabolized by CYP3A4. This simply means that calcium channel blockers, statins, some immunosuppressant drugs (like cyclosporine), and erectile dysfunction drugs such as sildenafil, may have increased blood levels. Please be cautious when taking resveratrol with anticoagulants or anti platelet drugs such as Plavix(r) (Clopidogrel). An increase in adenosine availability is involved in resveratrol cardioprotection in rats. It maybe possible that an increase in adenosine can increase uric acid temporarily. As a caution, it is not recommended long term for people with a genetic predisposition to Gout. We also advise the following: * Keep out of reach and do not give to children. * Do not exceed suggested maximum dose unless your doctor recommends it. * If you have a bad reaction to the supplement discontinue use immediately. * When undergoing treatment for any medical condition, are pregnant (or lactating) please inform your physician when using any nutritional supplements.